The National Library of Medicine published a paper on the website of "Oncology Therapy Electric Field (TTFields) Technology as an Overview of Potential Adjuvant Biophysical Therapy for COVID-19"
- Aug 1, 2025
- 1 min read
Paper abstract ~
The COVID-19 pandemic has affected millions of people around the world and killed tens of thousands. Although people are working to find drugs or vaccines, the key to whether patients can survive is still the immune system. Therefore, it is crucial to improve the efficacy and function of the immune system of COVID-19 patients. In this regard, a potential, novel, non-invasive, FDA-approved biophysical technology worth considering is the alternating electric field-based tumor treatment fields (TTFields), which have significant biological effects. TTFields play a significant role in improving the functions of dendritic cells and cytotoxic T cells, which play an important role in resisting viral infections. Therefore, applying TTFields can help COVID-19 patients fight infections. In addition, TTFields can also reduce replication of viral genome by reducing the expression of genes from some important members of the DNA replication complex (from the microchromosome maintenance family (MCMs). These genes are not only involved in DNA replication, but have also been shown to play a crucial role in viral replication. In addition, TTFields can also inhibit the formation of tunnel nanotubes (TNT) networks, which are known as filamentous (F)-actin-rich tubular structures. TNT plays a key role in promoting viral transmission by promoting viral invasion and acting as a protective agent to protect viral components in immune cells and even drugs. In addition, TTFields can also enhance autophagy, leading to apoptosis of viral infected cells. Therefore, it can be speculated that TTFields may prove to be a promising COVID-19-assisted treatment.