Paper published on the National Library of Medicine website: "Clinical trial of electroencephalosing stimulation in the treatment of anxiety and comorbid depression"
- Alex Xu
- Aug 1
- 1 min read
Paper abstract ~
Background: Anxiety is one of the most common mental disorders, usually with medication and/or psychotherapy. The treatment process is more complicated when anxiety is accompanied by comorbid depression. Drug adherence is a common problem due to adverse drug reactions, so new, effective and less side effects treatments need to be developed to treat anxiety and depression. This study was designed to evaluate the effectiveness of CES in primary care facilities for the treatment of anxiety and comorbid depression. This study has been registered with clinicaltrials.gov with registration number NCT01533415.
Methods: From February to December 2012, a total of 115 participants aged 18 and above who were mainly diagnosed with anxiety disorder were included. The Hamilton Anxiety Scale (HAM-A) and Hamilton Depression Scale 17 (HAM-D17) were used as baseline indicators, and the efficacy was evaluated at weeks 1, 3 and 5. Treatment response is defined as a decrease of ≥50% or more of the above indicators.
Results: Covariance analysis showed that from the study baseline to the study endpoint, the active CES group and the pseudo-CES group had significant differences in anxiety (p=0.001, d=0.94) and depression (p=0.001, d=0.78), and the active CES group was better.
Conclusion: CES significantly reduces anxiety and comorbid depression. Subjects did not report any adverse events during the study period.